The Brexit referendum in June 2016 and US President Donald Trump's moves to interrogate, change or exit from the existing world order point to the fact that the Western world, as we know it, is on the threshold of a catalytic upheaval. The long held liberal political underpinnings in America and Europe are giving way to a mixture of isolationist nationalism and shifting of alliances. Is it the beginning of the end of the existing world order that was established following WWII? Is a new world order being created? Africa must not sit by and be a spectator as the current events unfold. It is urgent that the continent urgently strategizes on how to navigate the impending new world order as it will have a domino effect on the continent.